› 6y76

X-ray diffraction
1.98Å resolution

AP01 - a redesigned transferrin receptor apical domain

Released:
DOI: 10.2210/pdb6y76/pdb
PDB entry 6y76 coloured by chain, front view.
PDB entry 6y76 coloured by chain, side view.
PDB entry 6y76 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Computational backbone design enables soluble engineering of transferrin receptor apical domain.
Sjöström DJ, Berger SA, Oberdorfer G, Bjelic S
Proteins 88 1569-1577 (2020)
PMID: 32592192

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transferrin receptor protein 1, serum form Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 18.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02786 (Residues: 197-378; Coverage: 20%)
Gene name: TFRC
Sequence domains: PA domain

Ligands and Environments

1 bound ligand:
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P21
Unit cell:
a: 33.122Å b: 119.558Å c: 33.167Å
α: 90° β: 112.249° γ: 90°
R-values:
R R work R free
0.238 0.234 0.274
Expression system: Escherichia coli

Quick links

Citations

3 mentions without citation

Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid.
Hong et al. (2021)
2 more