› 6xzc

Electron Microscopy
3.37Å resolution

CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb6xzc/pdb
PDB entry 6xzc coloured by chain, front view.
PDB entry 6xzc coloured by chain, side view.
PDB entry 6xzc coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis.
Piton J, Pojer F, Wakatsuki S, Gati C, Cole ST
J Struct Biol X 4 100029 (2020)
PMID: 32875288
Related structures: EMD-10658

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161686 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ESX-1 secretion-associated protein EspB Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 460 amino acids
Theoretical weight: 47.64 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WJD9 (Residues: 1-460; Coverage: 100%)
Gene names: MTV027.16c, Rv3881c, espB, mtb48
Sequence domains: ESX-1 secreted protein B PE domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.37Å
Relevant EMDB volumes: EMD-10658
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Modeling Tubercular ESX-1 Secretion Using Mycobacterium marinum.
Chirakos et al. (2020)
7 other articles

3 mentions without citation

Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM.
Bendre et al. (2021)
2 more