› 6xwu

X-ray diffraction
1.82Å resolution

Crystal structure of drosophila melanogaster CENP-C cumin domain

Released:
DOI: 10.2210/pdb6xwu/pdb
PDB entry 6xwu coloured by chain, front view.
PDB entry 6xwu coloured by chain, side view.
PDB entry 6xwu coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Medina-Pritchard B, Lazou V, Zou J, Byron O, Abad MA, Rappsilber J, Heun P, Jeyaprakash AA
EMBO J 39 e103234 (2020)
PMID: 32134144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FI18815p1 Chain: A
Molecule details ›
Chain: A
Length: 1411 amino acids
Theoretical weight: 157.99 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9VHP9 (Residues: 1-1411; Coverage: 100%)
Gene names: CENP-C, CG11745, CG11746, CG31258, CLD1, Cenp-C, Cenp-C-RA, CenpC, Dmel\CG31258, Dmel_CG31258, L1, cenp-C, dCENP-C, l(2)SH3 157, l(3)85Aa, l(3)SH157

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 57.195Å b: 57.195Å c: 92.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.194 0.235
Expression system: Escherichia coli

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Citations

6 review citations

The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle.
Kixmoeller et al. (2020)
5 more