› 6xno

X-ray diffraction
1.9Å resolution

Crystal structure of E99A mutant of human CEACAM1

Released:
DOI: 10.2210/pdb6xno/pdb
PDB entry 6xno coloured by chain, front view.
PDB entry 6xno coloured by chain, side view.
PDB entry 6xno coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS
Commun Biol 4 360 (2021)
PMID: 33742094

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carcinoembryonic antigen-related cell adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13688 (Residues: 35-141; Coverage: 22%)
Gene names: BGP, BGP1, CEACAM1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

2 bound ligands:
Ligand BOG 2 x BOG
Ligand MLA 2 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P4212
Unit cell:
a: 106.82Å b: 106.82Å c: 62.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.223
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Human CEACAM1 N-domain dimerization is independent from glycan modifications.
Belcher Dufrisne et al. (2022)
5 more

1 mention without citation

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
Gandhi et al. (2021)