› 6xnn

X-ray diffraction
2.49Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174810 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 21.46 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q3TBT3 (Residues: 154-340; Coverage: 50%)
Gene names: Eris, Mita, Mpys, Sting, Sting1, Tmem173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand V67 2 x V67
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 65.68Å b: 65.68Å c: 172.577Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.27
Expression system: Escherichia coli

Quick links

Citations

60 review citations

Turning cold tumors into hot tumors by improving T-cell infiltration.
Liu et al. (2021)
59 more

1 mention without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)