› 6wpq

X-ray diffraction
1.1Å resolution

GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant

Released:
DOI: 10.2210/pdb6wpq/pdb
PDB entry 6wpq coloured by chain, front view.
PDB entry 6wpq coloured by chain, side view.
PDB entry 6wpq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS
Nat Commun 11 4090 (2020)
PMID: 32796831

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149688 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heterogeneous nuclear ribonucleoproteins A2/B1 Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 713 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P22626 (Residues: 298-303; Coverage: 2%)
Gene names: HNRNPA2B1, HNRPA2B1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 4.78Å b: 19Å c: 20.74Å
α: 90° β: 95.71° γ: 90°
R-values:
R R work R free
0.077 0.074 0.104
Expression system: Not provided

Quick links

Citations

13 review citations

The expanding amyloid family: Structure, stability, function, and pathogenesis.
Sawaya et al. (2021)
12 more

2 mentions without citation

hnRNP A/B Proteins: An Encyclopedic Assessment of Their Roles in Homeostasis and Disease.
Thibault et al. (2021)
1 more