› 6wm9

X-ray diffraction
2.45Å resolution

Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 237235

Released:
DOI: 10.2210/pdb6wm9/pdb
PDB entry 6wm9 coloured by chain, front view.
PDB entry 6wm9 coloured by chain, side view.
PDB entry 6wm9 coloured by chain, top view.
Source organisms:
Primary publication:
Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Chan LJ, Gandhirajan A, Carias LL, Dietrich MH, Vadas O, Visentin R, França CT, Menant S, Soldati-Favre D, Mueller I, King CL, Tham WH
Nat Commun 12 1538 (2021)
PMID: 33750786

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207596 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
NBD94 domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 307 amino acids
Theoretical weight: 36.52 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K736 (Residues: 15-316; Coverage: 11%)
Gene name: PVX_094255
237235 Fab heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 235 amino acids
Theoretical weight: 25.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
237235 Fab light chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 221 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P1
Unit cell:
a: 61.9Å b: 86.78Å c: 90.77Å
α: 91.62° β: 109.98° γ: 99.88°
R-values:
R R work R free
0.226 0.223 0.279
Expression systems:
  • Escherichia coli
  • Homo sapiens

Quick links

Citations

3 review citations

Plasmodium vivax vaccine: What is the best way to go?
da Veiga et al. (2022)
2 more