› 6w7b

X-ray diffraction
3.88Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.3 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P97438 (Residues: 35-339; Coverage: 72%)
Gene name: Kcnk2
Sequence domains: Ion channel

Ligands and Environments

6 bound ligands:
Ligand CD 2 x CD
Ligand D12 3 x D12
Ligand OCT 2 x OCT
Ligand B7G 1 x B7G
Ligand K 2 x K
Ligand D10 1 x D10
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 66.906Å b: 122.597Å c: 125.576Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.276 0.275 0.309
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Structural Insights into the Mechanisms and Pharmacology of K2P Potassium Channels.
Natale et al. (2021)
4 more