› 6vxn

Electron Microscopy
2.96Å resolution

Cryo-EM structure of Arabidopsis thaliana MSL1 A320V

Released:
DOI: 10.2210/pdb6vxn/pdb
PDB entry 6vxn coloured by chain, front view.
PDB entry 6vxn coloured by chain, side view.
PDB entry 6vxn coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.
Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P
Nat Commun 11 3690 (2020)
PMID: 32704140
Related structures: EMD-21445

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mechanosensitive ion channel protein 1, mitochondrial Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 428 amino acids
Theoretical weight: 46.6 KDa
Source organism: Arabidopsis thaliana
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q8VZL4 (Residues: 79-497; Coverage: 84%)
Gene names: A_IG005I10.9, At4g00290, F5I10.9, MSL1
Sequence domains: Mechanosensitive ion channel, beta-domain

Ligands and Environments

1 bound ligand:
Ligand D12 7 x D12
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.96Å
Relevant EMDB volumes: EMD-21445
Expression system: Komagataella pastoris

Quick links

Citations

6 review citations

Discoveries in structure and physiology of mechanically activated ion channels.
Kefauver et al. (2020)
5 more

4 mentions without citation

Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.
Deng et al. (2020)
3 more