› 6vqk

Electron Microscopy
5.7Å resolution

Mammalian V-ATPase from rat brain collar and peripheral stalks rotational state 3 (from focused refinement)

Released:
DOI: 10.2210/pdb6vqk/pdb
PDB entry 6vqk coloured by chain, front view.
PDB entry 6vqk coloured by chain, side view.
PDB entry 6vqk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of V-ATPase from the mammalian brain.
Abbas YM, Wu D, Bueler SA, Robinson CV, Rubinstein JL
Science 367 1240-1246 (2020)
PMID: 32165585
Related structures: EMD-21353

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150411 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
V-type proton ATPase subunit C 1 Chain: G
Molecule details ›
Chain: G
Length: 382 amino acids
Theoretical weight: 43.96 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: Q5FVI6 (Residues: 1-382; Coverage: 100%)
Gene name: Atp6v1c1
Sequence domains: V-ATPase subunit C
V-type proton ATPase subunit E 1 Chains: I, J, K
Molecule details ›
Chains: I, J, K
Length: 226 amino acids
Theoretical weight: 26.17 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: Q6PCU2 (Residues: 1-226; Coverage: 100%)
Gene name: Atp6v1e1
Sequence domains: ATP synthase (E/31 kDa) subunit
V-type proton ATPase subunit G Chains: M, N, O
Molecule details ›
Chains: M, N, O
Length: 118 amino acids
Theoretical weight: 13.69 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: Q8R2H0 (Residues: 1-118; Coverage: 100%)
Gene names: Aif1, Atp6v1g2, Bat1a, Cdk2ap1-ps2, Cdk2ap1-ps3, Cdk2ap1-ps4, Cdk2ap1-ps5, Cdk2ap1-ps6, E230034O05Rik, LOC224733l-3, LOC224733l-4, LOC224733l-5, LOC224733l-6, LOC224733l-7, LOC224733l-8, Lst1, RT1-CE12, RT1-CE3, RT1-CE5, RT1-CE6, RT1-CE8, RT1-CE9, Sacm2l-ps3, Sacm2l-ps4, Sacm2l-ps5, Sacm2l-ps6, Sacm2l-ps7, Tnf
Sequence domains: Vacuolar (H+)-ATPase G subunit
V-type proton ATPase 116 kDa subunit a 1 Chain: a
Molecule details ›
Chain: a
Length: 838 amino acids
Theoretical weight: 96.43 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P25286 (Residues: 1-838; Coverage: 100%)
Gene names: Atp6n1, Atp6v0a1, Vpp1
Sequence domains: V-type ATPase 116kDa subunit family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.7Å
Relevant EMDB volumes: EMD-21353

Quick links

Citations

25 review citations

The assembly, regulation and function of the mitochondrial respiratory chain.
Vercellino et al. (2022)
24 more

1 mention without citation

Structure of V-ATPase from the mammalian brain.
Abbas et al. (2020)