› 6uzz

Electron Microscopy
3.1Å resolution

structure of human KCNQ1-CaM complex

Released:
DOI: 10.2210/pdb6uzz/pdb
PDB entry 6uzz coloured by chain, front view.
PDB entry 6uzz coloured by chain, side view.
PDB entry 6uzz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Human KCNQ1 Modulation and Gating.
Sun J, MacKinnon R
Cell 180 340-347.e9 (2020)
PMID: 31883792
Related structures: EMD-20965

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143983 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 557 amino acids
Theoretical weight: 63.26 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P51787 (Residues: 76-620; Coverage: 81%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1
Sequence domains:
Calmodulin-1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-20965
Expression system: Homo sapiens

Quick links

Citations

20 review citations

KCNQs: Ligand- and Voltage-Gated Potassium Channels.
Abbott GW. (2020)
19 more

24 mentions without citation

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.
Brewer et al. (2020)
23 more