› 6uw4

Electron Microscopy
3.1Å resolution

Cryo-EM structure of human TRPV3 determined in lipid nanodisc

Released:
DOI: 10.2210/pdb6uw4/pdb
PDB entry 6uw4 coloured by chain, front view.
PDB entry 6uw4 coloured by chain, side view.
PDB entry 6uw4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Gating of human TRPV3 in a lipid bilayer.
Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P
Nat Struct Mol Biol 27 635-644 (2020)
PMID: 32572252
Related structures: EMD-20917

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 790 amino acids
Theoretical weight: 90.73 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q8NET8 (Residues: 1-790; Coverage: 100%)
Gene name: TRPV3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 6OU 20 x 6OU
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-20917
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
7 more

8 mentions without citation

P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models.
Tikhonov et al. (2022)
7 more