› 6ujv

Solution NMR

Model of the HIV-1 gp41 membrane-proximal external region, transmembrane domain and cytoplasmic tail (LLP2)

Released:
DOI: 10.2210/pdb6ujv/pdb
PDB entry 6ujv coloured by chain, ensemble of 15 models, front view.
PDB entry 6ujv coloured by chain, ensemble of 15 models, side view.
PDB entry 6ujv coloured by chain, ensemble of 15 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein.
Piai A, Fu Q, Cai Y, Ghantous F, Xiao T, Shaik MM, Peng H, Rits-Volloch S, Chen W, Seaman MS, Chen B, Chou JJ
Nat Commun 11 2317 (2020)
PMID: 32385256

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 129 amino acids
Theoretical weight: 15.17 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04578 (Residues: 660-788; Coverage: 16%)
Gene name: env
Sequence domains: Retroviral envelope protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 9%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Vaccine delivery systems toward lymph nodes.
Ding et al. (2021)
4 more

5 mentions without citation

Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein.
Piai et al. (2020)
4 more