› 6u67

X-ray diffraction
1.84Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 156 amino acids
Theoretical weight: 17.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 171-323; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family

Ligands and Environments

2 bound ligands:
Ligand Q01 6 x Q01
Ligand BNL 2 x BNL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2221
Unit cell:
a: 67.514Å b: 134.376Å c: 70.794Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.222
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Targeting MCL-1 in cancer: current status and perspectives.
Wang et al. (2021)
2 more

1 mention without citation

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Kump et al. (2020)