6twy

X-ray diffraction
2.3Å resolution

MAGI1_2 complexed with a phosphomimetic RSK1 peptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-139546 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Annexin A2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 427 amino acids
Theoretical weight: 48.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96QZ7 (Residues: 458-558; Coverage: 7%)
  • Canonical: P07355 (Residues: 22-339; Coverage: 94%)
Gene names: AIP3, ANX2, ANX2L4, ANXA2, BAIAP1, BAP1, CAL1H, LPC2D, MAGI1, TNRC19
Sequence domains:
Ribosomal protein S6 kinase alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.37 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15418 (Residues: 725-735; Coverage: 2%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Unit cell:
a: 61.45Å b: 96.38Å c: 198.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.25
Expression systems:
  • Escherichia coli
  • Not provided