› 6tw8

X-ray diffraction
1.79Å resolution

Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917

Released:
DOI: 10.2210/pdb6tw8/pdb
PDB entry 6tw8 coloured by chain, front view.
PDB entry 6tw8 coloured by chain, side view.
PDB entry 6tw8 coloured by chain, top view.
Source organism: Leishmania major
Entry author: Brannigan JA

Function and Biology Details

Reaction catalysed: 
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase Chains: AAA, CCC
Molecule details ›
Chains: AAA, CCC
Length: 418 amino acids
Theoretical weight: 48.2 KDa
Source organism: Leishmania major
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q4Q5S8 (Residues: 4-421; Coverage: 99%)
Gene names: LMJF_32_0080, NMT
Sequence domains:

Ligands and Environments


Cofactor: Ligand MYA 2 x MYA
2 bound ligands:
Ligand 9M2 2 x 9M2
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 53.02Å b: 89.82Å c: 97.18Å
α: 90° β: 104.27° γ: 90°
R-values:
R R work R free
0.22 0.218 0.264
Expression system: Escherichia coli BL21(DE3)

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