› 6ts4

X-ray diffraction
1.17Å resolution

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137278 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin

Ligands and Environments

4 bound ligands:
Ligand SO4 3 x SO4
Ligand DMS 5 x DMS
Ligand NA 1 x NA
Ligand J7B 1 x J7B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 60.32Å b: 60.8Å c: 66.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.203
Expression system: Escherichia coli K-12

Quick links

Citations

1 citations in other articles

Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives.
Sergazy et al. (2022)

1 mention without citation

Screening of Potential Anti-Thrombotic Ingredients from Salvia miltiorrhiza in Zebrafish and by Molecular Docking.
Tang et al. (2021)