› 6tm6

X-ray diffraction
1.63Å resolution

MUC2 CysD1 domain

Released:
DOI: 10.2210/pdb6tm6/pdb
PDB entry 6tm6 coloured by chain, front view.
PDB entry 6tm6 coloured by chain, side view.
PDB entry 6tm6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Javitt G, Khmelnitsky L, Albert L, Bigman LS, Elad N, Morgenstern D, Ilani T, Levy Y, Diskin R, Fass D
Cell 183 717-729.e16 (2020)
PMID: 33031746

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucin-2 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02817 (Residues: 1301-1395; Coverage: 2%)
Gene names: MUC2, SMUC
Sequence domains: Mucin-2 protein WxxW repeating region

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P21212
Unit cell:
a: 54.879Å b: 57.854Å c: 27.471Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.211
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Physiology and pathophysiology of human airway mucus.
Hill et al. (2022)
12 more

3 mentions without citation

The Biological Synthesis and the Function of Mucin 2 in Pseudomyxoma Peritonei.
Lin et al. (2021)
2 more