› 6sx7

X-ray diffraction
2.5Å resolution

Crystal Structure of the Voltage-Gated Sodium Channel NavMs (F208L) (2.2 Angstrom resolution)

Released:
DOI: 10.2210/pdb6sx7/pdb
PDB entry 6sx7 coloured by chain, front view.
PDB entry 6sx7 coloured by chain, side view.
PDB entry 6sx7 coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
A tamoxifen receptor within a voltage-gated sodium channel.
Sula A, Hollingworth D, Ng LCT, Larmore M, DeCaen PG, Wallace BA
Mol Cell 81 1160-1169.e5 (2021)
PMID: 33503406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.19 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A0L5S6 (Residues: 1-274; Coverage: 100%)
Gene name: Mmc1_0798
Sequence domains: Ion transport protein

Ligands and Environments

4 bound ligands:
Ligand NA 3 x NA
Ligand 2CV 2 x 2CV
Ligand 12P 1 x 12P
Ligand ME2 1 x ME2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I422
Unit cell:
a: 109.004Å b: 109.004Å c: 208.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.232 0.247
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The Interface of Nuclear and Membrane Steroid Signaling.
Treviño et al. (2021)
3 more

1 mention without citation

A tamoxifen receptor within a voltage-gated sodium channel.
Sula et al. (2021)