› 6sub

X-ray diffraction
1.72Å resolution

Human PTPRU D1 domain, reduced form

Released:
DOI: 10.2210/pdb6sub/pdb
PDB entry 6sub coloured by chain, front view.
PDB entry 6sub coloured by chain, side view.
PDB entry 6sub coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The receptor PTPRU is a redox sensitive pseudophosphatase.
Hay IM, Fearnley GW, Rios P, Köhn M, Sharpe HJ, Deane JE
Nat Commun 11 3219 (2020)
PMID: 32591542

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase U Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 34.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92729 (Residues: 871-1153; Coverage: 20%)
Gene names: FMI, PCP2, PTPRO, PTPRU
Sequence domains: Protein-tyrosine phosphatase

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 61.821Å b: 107.887Å c: 88.328Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.201
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Protein tyrosine phosphatases in cell adhesion.
Young et al. (2021)
2 more