› 6snw

Electron Microscopy
3.9Å resolution

Structure of Coxsackievirus A10 complexed with its receptor KREMEN1

Released:
DOI: 10.2210/pdb6snw/pdb
PDB entry 6snw coloured by chain, front view.
PDB entry 6snw coloured by chain, side view.
PDB entry 6snw coloured by chain, top view.
Source organisms:
Primary publication:
Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Zhao Y, Zhou D, Ni T, Karia D, Kotecha A, Wang X, Rao Z, Jones EY, Fry EE, Ren J, Stuart DI
Nat Commun 11 38 (2020)
PMID: 31911601
Related structures: EMD-10263

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 300-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179818 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.19 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: Q6JKR9 (Residues: 565-862; Coverage: 14%)
Sequence domains: picornavirus capsid protein
Coxsackievirus VP2 Chain: B
Molecule details ›
Chain: B
Length: 255 amino acids
Theoretical weight: 27.73 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: Q6JKR9 (Residues: 70-324; Coverage: 12%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 240 amino acids
Theoretical weight: 26.22 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: Q6JKR9 (Residues: 325-564; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Coxsackievirus VP4 Chain: D
Molecule details ›
Chain: D
Length: 69 amino acids
Theoretical weight: 7.46 KDa
Source organism: Coxsackievirus A10
UniProt:
  • Canonical: Q6JKR9 (Residues: 1-69; Coverage: 3%)
Sequence domains: Picornavirus coat protein (VP4)
Kremen protein 1 Chain: E
Molecule details ›
Chain: E
Length: 378 amino acids
Theoretical weight: 41.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96MU8 (Residues: 23-30, 31-324, 326-373; Coverage: 77%)
Gene names: KREMEN, KREMEN1, KRM1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand SPH 1 x SPH
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-10263
Expression system: Homo sapiens

Quick links

Citations

3 review citations

'Tomato flu' a new epidemic in India: Virology, epidemiology, and clinical features.
Ismail et al. (2023)
2 more

1 mention without citation

N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection.
Jayawardena et al. (2021)