› 6sfo

X-ray diffraction
1.75Å resolution

MAPK14 with bound inhibitor SR-318

Released:
DOI: 10.2210/pdb6sfo/pdb
PDB entry 6sfo coloured by chain, front view.
PDB entry 6sfo coloured by chain, side view.
PDB entry 6sfo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Schroeder M, Edwards AM, Arrowsmith CH, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand LBE 1 x LBE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 65.516Å b: 75.051Å c: 77.486Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.236
Expression system: Escherichia coli

Quick links