› 6sf6

X-ray diffraction
1.9Å resolution

Crystal structure of the mAb 15A in complex with COMP-epitope P6

Released:
DOI: 10.2210/pdb6sf6/pdb
PDB entry 6sf6 coloured by chain, front view.
PDB entry 6sf6 coloured by chain, side view.
PDB entry 6sf6 coloured by chain, top view.
Source organisms:
Entry authors: Dobritzsch D, Ge C, Holmdahl R

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211112 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 233 amino acids
Theoretical weight: 25.39 KDa
Source organism: Mus musculus
Expression system: Mus musculus
COMP-reactive monoclonal antibody 15A Fab fragment, light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 219 amino acids
Theoretical weight: 24.24 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Cartilage oligomeric matrix protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.12 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P35444 (Residues: 232-250; Coverage: 3%)
Gene name: Comp

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 6 x GOL
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 80.174Å b: 84.421Å c: 151.885Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.203
Expression systems:
  • Mus musculus
  • Not provided

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