› 6sa4

X-ray diffraction
1.77Å resolution

SALSA / DMBT1 / GP340 SRCR domain 1

Released:
DOI: 10.2210/pdb6sa4/pdb
PDB entry 6sa4 coloured by chain, front view.
PDB entry 6sa4 coloured by chain, side view.
PDB entry 6sa4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Reichhardt MP, Loimaranta V, Lea SM, Johnson S
Life Sci Alliance 3 (2020)
PMID: 32098784

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deleted in malignant brain tumors 1 protein Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q9UGM3 (Residues: 95-203; Coverage: 5%)
Gene names: DMBT1, GP340
Sequence domains: Scavenger receptor cysteine-rich domain

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand CL 1 x CL
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 36.77Å b: 45.19Å c: 69.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.229
Expression system: Drosophila melanogaster

Quick links

Citations

3 review citations

S Protein, ACE2 and Host Cell Proteases in SARS-CoV-2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? A Narrative Review.
Nejat et al. (2023)
2 more

2 mentions without citation

Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Reichhardt et al. (2020)
1 more