› 6s4u

X-ray diffraction
2.81Å resolution

LXRbeta ligand binding domain in comlpex with small molecule inhibitors

Released:
DOI: 10.2210/pdb6s4u/pdb
PDB entry 6s4u coloured by chain, front view.
PDB entry 6s4u coloured by chain, side view.
PDB entry 6s4u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
Belorusova AY, Evertsson E, Hovdal D, Sandmark J, Bratt E, Maxvall I, Schulman IG, Åkerblad P, Lindstedt EL
Commun Biol 2 431 (2019)
PMID: 31799433

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 245 amino acids
Theoretical weight: 28.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55055 (Residues: 216-460; Coverage: 53%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand KVK 3 x KVK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 125.086Å b: 125.086Å c: 137.054Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.254 0.253 0.28
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Lipid metabolism in cancer progression and therapeutic strategies.
Fu et al. (2021)
4 more

1 mention without citation

Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids.
Jaladanki et al. (2021)