› 6rqq

X-ray diffraction
1.28Å resolution

X-ray crystal structure of protiated (H) large monoclinic unit cell CA IX SV.

Released:
DOI: 10.2210/pdb6rqq/pdb
PDB entry 6rqq coloured by chain, front view.
PDB entry 6rqq coloured by chain, side view.
PDB entry 6rqq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX.
Koruza K, Lafumat B, Nyblom M, Mahon BP, Knecht W, McKenna R, Fisher SZ
Acta Crystallogr D Struct Biol 75 895-903 (2019)
PMID: 31588921

Function and Biology Details

Reaction catalysed: 
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase 9 Chains: A, C
Molecule details ›
Chains: A, C
Length: 256 amino acids
Theoretical weight: 28.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16790 (Residues: 140-395; Coverage: 61%)
Gene names: CA9, G250, MN
Sequence domains: Eukaryotic-type carbonic anhydrase

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand FMT 2 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P21
Unit cell:
a: 48.94Å b: 65.1Å c: 76.29Å
α: 90° β: 92.86° γ: 90°
R-values:
R R work R free
0.182 0.181 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX.
Koruza et al. (2020)
5 more

2 mentions without citation

Pyridinium derivatives of 3-aminobenzenesulfonamide are nanomolar-potent inhibitors of tumor-expressed carbonic anhydrase isozymes CA IX and CA XII.
Akocak et al. (2020)
1 more