6r2g

X-ray diffraction
1.9Å resolution

Crystal structure of a single-chain protein mimetic of the gp41 NHR trimer in complex with the synthetic CHR peptide C34

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-136945 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.18 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P03377 (Residues: 546-597, 598-650, 549-599; Coverage: 15%)
Gene name: env
Sequence domains: Retroviral envelope protein
Transmembrane protein gp41 Chain: C
Molecule details ›
Chain: C
Length: 36 amino acids
Theoretical weight: 4.28 KDa
Source organism: Human immunodeficiency virus type 1 (BRU ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P03377 (Residues: 632-666; Coverage: 4%)
Gene name: env

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 27.201Å b: 69.664Å c: 95.836Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.231
Expression system: Escherichia coli