› 6qgd

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1; Maltose/maltodextrin-binding periplasmic protein Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 57.23 KDa
Source organisms: Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: Q07820 (Residues: 173-321; Coverage: 43%)
Gene names: BCL2L3, JW3994, MCL1, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
2 bound ligands:
Ligand J1N 1 x J1N
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 100.48Å b: 135.75Å c: 38.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.208
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs.
Diepstraten et al. (2022)
3 more

2 mentions without citation

Structural insights into apoptotic regulation of human Bfk as a novel Bcl-2 family member.
Jang et al. (2022)
1 more