› 6q4j

X-ray diffraction
1.05Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand DMS 2 x DMS
Ligand HHB 1 x HHB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 53.123Å b: 72.348Å c: 71.886Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.166 0.186
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Fragment-based drug discovery-the importance of high-quality molecule libraries.
Bon et al. (2022)
1 more

1 mention without citation

Cosolvent Analysis Toolkit (CAT): a robust hotspot identification platform for cosolvent simulations of proteins to expand the druggable proteome.
Sabanés Zariquiey et al. (2019)