› 6pyo

X-ray diffraction
2Å resolution

Calcium Activated Chloride Channel Regulator 1 (CLCA1) VWA Domain

Released:
DOI: 10.2210/pdb6pyo/pdb
PDB entry 6pyo coloured by chain, front view.
PDB entry 6pyo coloured by chain, side view.
PDB entry 6pyo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.
Berry KN, Brett TJ
Cell Rep 30 1141-1151.e3 (2020)
PMID: 31995732

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108713 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated chloride channel regulator 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 187 amino acids
Theoretical weight: 19.81 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A8K7I4 (Residues: 302-476; Coverage: 20%)
Gene names: CACC1, CLCA1
Sequence domains: von Willebrand factor type A domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 104.86Å b: 71.78Å c: 74.84Å
α: 90° β: 109.761° γ: 90°
R-values:
R R work R free
0.199 0.197 0.225
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels.
Hawn et al. (2021)
1 more

1 mention without citation

Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.
Berry et al. (2020)