› 6pyb

X-ray diffraction
1.8Å resolution

Sex Hormone-binding globulin mutant E176K in complex with DVT

Released:
DOI: 10.2210/pdb6pyb/pdb
PDB entry 6pyb coloured by chain, front view.
PDB entry 6pyb coloured by chain, side view.
PDB entry 6pyb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL
J Biol Chem 295 1202-1211 (2020)
PMID: 31852737

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 22.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 30-234; Coverage: 55%)
Gene name: SHBG
Sequence domains: Laminin G domain

Ligands and Environments

2 bound ligands:
Ligand P5G 1 x P5G
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4322
Unit cell:
a: 51.953Å b: 51.953Å c: 148.354Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.231
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function.
Rouhimoghadam et al. (2020)
2 more

3 mentions without citation

Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
Round et al. (2020)
2 more