› 6psa

X-ray diffraction
1.3Å resolution

PIE12 D-PEPTIDE AGAINST HIV ENTRY (IN COMPLEX WITH IQN17 Q577R RESISTANCE MUTANT)

Released:
DOI: 10.2210/pdb6psa/pdb
PDB entry 6psa coloured by chain, front view.
PDB entry 6psa coloured by chain, side view.
PDB entry 6psa coloured by chain, top view.
Source organisms:
Primary publication:
Characterization of resistance to a potent D-peptide HIV entry inhibitor.
Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS
Retrovirology 16 28 (2019)
PMID: 31640718

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136500 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General control transcription factor GCN4; Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.54 KDa
Source organisms: Expression system: Not provided
UniProt:
  • Canonical: P03069 (Residues: 249-277; Coverage: 10%)
  • Canonical: P04578 (Residues: 566-581; Coverage: 2%)
Gene names: AAS101, AAS3, ARG9, GCN4, YEL009C, env
Sequence domains: Basic region leucine zipper
PIE12 D-peptide Chain: H
Molecule details ›
Chain: H
Length: 18 amino acids
Theoretical weight: 2.03 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
11 modified residues:
Ligand DLY 1 x DLY
Ligand DHI 1 x DHI
Ligand DPR 2 x DPR
Ligand DCY 2 x DCY
Ligand DAS 1 x DAS
Ligand DTY 1 x DTY
Ligand DGL 2 x DGL
Ligand DTR 2 x DTR
Ligand DGN 1 x DGN
Ligand DLE 2 x DLE
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: R3
Unit cell:
a: 48.843Å b: 48.843Å c: 67.634Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.176 0.217
Expression system: Not provided

Quick links

Citations

1 review citation

Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus.
Anasir et al. (2020)
3 other articles

2 mentions without citation

An Automated Micro-Total Immunoassay System for Measuring Cancer-Associated α2,3-linked Sialyl N-Glycan-Carrying Prostate-Specific Antigen May Improve the Accuracy of Prostate Cancer Diagnosis.
Ishikawa et al. (2017)
1 more