› 6pkv

Electron Microscopy
4.3Å resolution

Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry

Released:
DOI: 10.2210/pdb6pkv/pdb
PDB entry 6pkv coloured by chain, front view.
PDB entry 6pkv coloured by chain, side view.
PDB entry 6pkv coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun 10 3740 (2019)
PMID: 31431622
Related structures: EMD-20367

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1466 amino acids
Theoretical weight: 167.61 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0R4IMY7 (Residues: 32-1470; Coverage: 95%)
Gene name: trpm2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-20367
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
9 more

5 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
4 more