› 6pef

X-ray diffraction
2Å resolution

Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519)

Released:
DOI: 10.2210/pdb6pef/pdb
PDB entry 6pef coloured by chain, front view.
PDB entry 6pef coloured by chain, side view.
PDB entry 6pef coloured by chain, top view.
Source organisms:
Entry authors: Xu K, Liu K, Wang Y, Kwong PD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209084 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
antibody DF2F-a.01 heavy chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 226 amino acids
Theoretical weight: 23.79 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
antibody DF2F-a.01 light chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 216 amino acids
Theoretical weight: 22.65 KDa
Source organism: Macaca mulatta
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: C, F
Molecule details ›
Chains: C, F
Length: 8 amino acids
Theoretical weight: 733 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 512-519; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 72.574Å b: 52.504Å c: 151.716Å
α: 90° β: 90.68° γ: 90°
R-values:
R R work R free
0.184 0.183 0.214
Expression systems:
  • Homo sapiens
  • Not provided

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