› 6ove

X-ray diffraction
2Å resolution

Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-propylphenyl-ACEPC

Released:
DOI: 10.2210/pdb6ove/pdb
PDB entry 6ove coloured by chain, front view.
PDB entry 6ove coloured by chain, side view.
PDB entry 6ove coloured by chain, top view.
Source organism: Rattus norvegicus
Entry authors: Syrenne JT, Mou TC, Tamborini L, Pinto A, Sprang SR, Hansen KB

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-152907 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-544, 663-800; Coverage: 31%)
Gene names: Grin1, Nmdar1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2A Chain: B
Molecule details ›
Chain: B
Length: 282 amino acids
Theoretical weight: 31.67 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00959 (Residues: 402-539, 568-801; Coverage: 19%)
Gene name: Grin2a
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand GLY 1 x GLY
Ligand N9D 1 x N9D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 54.694Å b: 86.987Å c: 121.984Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.216
Expression system: Escherichia coli

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