› 6oon

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190782 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Protein argonaute-4 Chain: A
Molecule details ›
Chain: A
Length: 863 amino acids
Theoretical weight: 97.37 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q9HCK5 (Residues: 1-861; Coverage: 100%)
Gene names: AGO4, EIF2C4, KIAA1567
Sequence domains:
RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.86 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 213.98Å b: 68.011Å c: 83.27Å
α: 90° β: 102.68° γ: 90°
R-values:
R R work R free
0.173 0.171 0.202
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

8 review citations

The interplay between m6A RNA methylation and noncoding RNA in cancer.
Ma et al. (2019)
7 more

5 mentions without citation

A Structural View of miRNA Biogenesis and Function.
Leitão et al. (2022)
4 more