› 6o8d

X-ray diffraction
3.55Å resolution

Anti-CD28xCD3 CODV Fab bound to CD28

Released:
DOI: 10.2210/pdb6o8d/pdb
PDB entry 6o8d coloured by chain, front view.
PDB entry 6o8d coloured by chain, side view.
PDB entry 6o8d coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lord DM, Wei RR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231749 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
T-cell-specific surface glycoprotein CD28 Chain: C
Molecule details ›
Chain: C
Length: 126 amino acids
Theoretical weight: 14.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P10747 (Residues: 19-136; Coverage: 58%)
Gene name: CD28
Sequence domains: ICOS V-set domain
Anti-CD28xCD3 CODV Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 338 amino acids
Theoretical weight: 36.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Anti-CD28xCD3 CODV Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 358 amino acids
Theoretical weight: 39.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 153.14Å b: 60.139Å c: 152.558Å
α: 90° β: 104.04° γ: 90°
R-values:
R R work R free
0.281 0.272 0.356
Expression system: Homo sapiens

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