› 6o6h

X-ray diffraction
2.5Å resolution

RIAM cc-RA-PH structure in the P21212 space group

Released:
DOI: 10.2210/pdb6o6h/pdb
PDB entry 6o6h coloured by chain, front view.
PDB entry 6o6h coloured by chain, side view.
PDB entry 6o6h coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
Cho EA, Zhang P, Kumar V, Kavalchuk M, Zhang H, Huang Q, Duncan JS, Wu J
Structure 29 320-329.e4 (2021)
PMID: 33275877

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 34.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8R5A3 (Residues: 150-437; Coverage: 43%)
Gene names: Apbb1ip, Prel1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21212
Unit cell:
a: 84.146Å b: 92.981Å c: 44.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.229 0.281
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The complex role of tumor-infiltrating macrophages.
Christofides et al. (2022)
4 more

2 mentions without citation

Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
Cho et al. (2021)
1 more