› 6o68

X-ray diffraction
2.78Å resolution

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Ciglitazone

Released:
DOI: 10.2210/pdb6o68/pdb
PDB entry 6o68 coloured by chain, front view.
PDB entry 6o68 coloured by chain, side view.
PDB entry 6o68 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Quantitative structural assessment of graded receptor agonism.
Shang J, Brust R, Griffin PR, Kamenecka TM, Kojetin DJ
Proc Natl Acad Sci U S A 116 22179-22188 (2019)
PMID: 31611383

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand LO4 1 x LO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 92.39Å b: 59.96Å c: 117.61Å
α: 90° β: 103.02° γ: 90°
R-values:
R R work R free
0.24 0.233 0.298
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Cooperativity as quantification and optimization paradigm for nuclear receptor modulators.
de Vink et al. (2022)
5 more

1 mention without citation

Quantitative structural assessment of graded receptor agonism.
Shang et al. (2019)