› 6nt7

Electron Microscopy
4Å resolution

Cryo-EM structure of full-length chicken STING in the cGAMP-bound dimeric state

Released:
DOI: 10.2210/pdb6nt7/pdb
PDB entry 6nt7 coloured by chain, front view.
PDB entry 6nt7 coloured by chain, side view.
PDB entry 6nt7 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.
Shang G, Zhang C, Chen ZJ, Bai XC, Zhang X
Nature 567 389-393 (2019)
PMID: 30842659
Related structures: EMD-0504

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122781 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 392 amino acids
Theoretical weight: 44.21 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: E1C7U0 (Residues: 1-379; Coverage: 100%)
Gene names: STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand 1SY 1 x 1SY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-0504
Expression system: Homo sapiens

Quick links

Citations

98 review citations

Molecular mechanisms and cellular functions of cGAS-STING signalling.
Hopfner et al. (2020)
97 more

17 mentions without citation

The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout et al. (2021)
16 more