› 6n3u

Electron crystallography
2.9Å resolution

MicroED Structure of the CTD-SP1 fragment of HIV-1 Gag with bound maturation inhibitor Bevirimat.

Released:
DOI: 10.2210/pdb6n3u/pdb
PDB entry 6n3u coloured by chain, front view.
PDB entry 6n3u coloured by chain, side view.
PDB entry 6n3u coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat.
Purdy MD, Shi D, Chrustowicz J, Hattne J, Gonen T, Yeager M
Proc Natl Acad Sci U S A 115 13258-13263 (2018)
PMID: 30530702
Related structures: EMD-0337

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 110 amino acids
Theoretical weight: 12.19 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04591 (Residues: 278-377; Coverage: 20%)
Gene name: gag
Sequence domains: Gag protein p24 C-terminal domain
Structure domains: Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-0337
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

3D Electron Diffraction: The Nanocrystallography Revolution.
Gemmi et al. (2019)
21 more

4 mentions without citation

Viral structural proteins as targets for antivirals.
Schlicksup et al. (2020)
3 more