› 6mqf

X-ray diffraction
1.69Å resolution

Myotoxin II from Bothrops moojeni complexed with Acetylsalicylic acid

Released:
DOI: 10.2210/pdb6mqf/pdb
PDB entry 6mqf coloured by chain, front view.
PDB entry 6mqf coloured by chain, side view.
PDB entry 6mqf coloured by chain, top view.
Source organism: Bothrops moojeni
Primary publication:
Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches.
Salvador GHM, Cardoso FF, Gomes AA, Cavalcante WLG, Gallacci M, Fontes MRM
Sci Rep 9 510 (2019)
PMID: 30679550

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191507 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog myotoxin II Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 13.91 KDa
Source organism: Bothrops moojeni
UniProt:
  • Canonical: Q9I834 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand DMS 3 x DMS
Ligand AIN 2 x AIN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P21
Unit cell:
a: 39.553Å b: 65.54Å c: 55.121Å
α: 90° β: 92.72° γ: 90°
R-values:
R R work R free
0.18 0.179 0.218

Quick links

Citations

1 review citation

Amplification of Snake Venom Toxicity by Endogenous Signaling Pathways.
Bickler PE. (2020)
4 other articles

3 mentions without citation

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920).
Salvador et al. (2019)
2 more