› 6mi2

X-ray diffraction
2.72Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211942 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Utomilumab Fab heavy chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 230 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Utomilumab Fab lambda chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 214 amino acids
Theoretical weight: 22.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Tumor necrosis factor receptor superfamily member 9 Chains: C, F
Molecule details ›
Chains: C, F
Length: 145 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q07011 (Residues: 25-162; Coverage: 60%)
Gene names: CD137, ILA, TNFRSF9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand SO4 20 x SO4
Ligand GOL 9 x GOL
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Unit cell:
a: 136.903Å b: 73.338Å c: 175.121Å
α: 90° β: 98.99° γ: 90°
R-values:
R R work R free
0.24 0.238 0.278
Expression systems:
  • Homo sapiens
  • Trichoplusia ni

Quick links

Citations

22 review citations

CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drug Development.
Hashimoto K. (2021)
21 more

3 mentions without citation

Broad specificity of immune helminth scFv library to identify monoclonal antibodies targeting Strongyloides.
Rahumatullah et al. (2021)
2 more