› 6mfp

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231531 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: A, G
Molecule details ›
Chains: A, G
Length: 355 amino acids
Theoretical weight: 39.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120
M48U1 CD4 MIMETIC PEPTIDE Chains: M, N
Molecule details ›
Chains: M, N
Length: 28 amino acids
Theoretical weight: 3.06 KDa
Source organism: synthetic construct
Expression system: Not provided
DH677.3 Fab heavy chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 228 amino acids
Theoretical weight: 24.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
DH677.3 Fab light chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 214 amino acids
Theoretical weight: 23.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 23 x NAG
Ligand CL 2 x CL
2 modified residues:
Ligand DPR 2 x DPR
Ligand U2X 2 x U2X

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P1
Unit cell:
a: 63.487Å b: 80.093Å c: 88.688Å
α: 84.82° β: 82.33° γ: 82.24°
R-values:
R R work R free
0.217 0.214 0.274
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

HIV and SARS-CoV-2: Tracing a Path of Vaccine Research and Development.
Shepherd et al. (2022)
1 more

4 mentions without citation

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.
Easterhoff et al. (2020)
3 more