› 6m6e

Solution NMR

Solution structure of the core domain of Fibroblast growth factor 21 (FGF21)

Released:
DOI: 10.2210/pdb6m6e/pdb
PDB entry 6m6e coloured by chain, ensemble of 10 models, front view.
PDB entry 6m6e coloured by chain, ensemble of 10 models, side view.
PDB entry 6m6e coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Dynamic folding modulation generates FGF21 variant against diabetes.
Zhu L, Zhao H, Liu J, Cai H, Wu B, Liu Z, Zhou S, Liu Q, Li X, Bao B, Liu J, Dai H, Wang J
EMBO Rep 22 e51352 (2021)
PMID: 33295692

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 21 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q9NSA1 (Residues: 42-169; Coverage: 71%)
Gene names: FGF21, UNQ3115/PRO10196
Sequence domains: Fibroblast growth factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli K-12

Quick links

Citations

5 review citations

The Saga of Endocrine FGFs.
Phan et al. (2021)
4 more

2 mentions without citation

Mangiferin Ameliorates Obesity-Associated Inflammation and Autophagy in High-Fat-Diet-Fed Mice: In Silico and In Vivo Approaches.
Noh et al. (2022)
1 more