› 6lxy

X-ray diffraction
2.19Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B, D, E
Molecule details ›
Chains: A, B, D, E
Length: 305 amino acids
Theoretical weight: 34.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 160-460; Coverage: 65%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand EXF 4 x EXF
Ligand SO4 3 x SO4
2 modified residues:
Ligand TPO 4 x TPO
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 135.67Å b: 140.81Å c: 86.28Å
α: 90° β: 125.7° γ: 90°
R-values:
R R work R free
0.202 0.201 0.231
Expression system: Spodoptera frugiperda

Quick links

Citations

1 citations in other articles

Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors.
Chen et al. (2022)

1 mention without citation

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.
Nair et al. (2020)