› 6ln4

X-ray diffraction
2.61Å resolution

Estrogen-related receptor beta(ERR2) in complex with PGC1a-2a

Released:
DOI: 10.2210/pdb6ln4/pdb
PDB entry 6ln4 coloured by chain, front view.
PDB entry 6ln4 coloured by chain, side view.
PDB entry 6ln4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into the Specificity of Ligand Binding and Coactivator Assembly by Estrogen-Related Receptor β.
Yao B, Zhang S, Wei Y, Tian S, Lu Z, Jin L, He Y, Xie W, Li Y
J Mol Biol 432 5460-5472 (2020)
PMID: 32795533

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132001 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Steroid hormone receptor ERR2 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 26.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95718 (Residues: 204-432; Coverage: 53%)
Gene names: ERRB2, ESRL2, ESRRB, NR3B2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBK2 (Residues: 207-216; Coverage: 1%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6522
Unit cell:
a: 108.472Å b: 108.472Å c: 106.902Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.245
Expression system: Escherichia coli

Quick links

Citations

2 review citations

In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An Overview.
Wang et al. (2021)
1 more