› 6la7

Electron Microscopy
2.82Å resolution

Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5

Released:
DOI: 10.2210/pdb6la7/pdb
PDB entry 6la7 coloured by chain, front view.
PDB entry 6la7 coloured by chain, side view.
PDB entry 6la7 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular and structural basis of Echovirus 11 infection by using the dual-receptor system of CD55 and FcRn.
Niu S, Liu C, Liu C, Liu S, Song Y, Zhang Y, Tian W, Zhao X, Wang P, Gao FG
Chin. Sci. Bull. (2020)
Related structures: EMD-0858

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-102661 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.28 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: Q2LJ73 (Residues: 3-287; Coverage: 98%)
Sequence domains: picornavirus capsid protein
Capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 251 amino acids
Theoretical weight: 27.97 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: A0A0R5YS56 (Residues: 80-330; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP3 Chain: C
Molecule details ›
Chain: C
Length: 238 amino acids
Theoretical weight: 26.06 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: A0A346I7K2 (Residues: 332-569; Coverage: 11%)
Sequence domains: picornavirus capsid protein
Capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 70 amino acids
Theoretical weight: 7.57 KDa
Source organism: Echovirus E11
UniProt:
  • Canonical: E0WN77 (Residues: 1-19, 20-69; Coverage: 47%)
Sequence domains: Picornavirus coat protein (VP4)
IgG receptor FcRn large subunit p51 Chain: E
Molecule details ›
Chain: E
Length: 263 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 28-290; Coverage: 77%)
Gene names: FCGRT, FCRN
Sequence domains:
Beta-2-microglobulin Chain: F
Molecule details ›
Chain: F
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.82Å
Relevant EMDB volumes: EMD-0858
Expression system: Homo sapiens

Quick links