› 6l62

Electron Microscopy
7.2Å resolution

Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope

Released:
DOI: 10.2210/pdb6l62/pdb
PDB entry 6l62 coloured by chain, front view.
PDB entry 6l62 coloured by chain, side view.
PDB entry 6l62 coloured by chain, top view.
Source organisms:
Primary publication:
Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
Huang L, Sun Z, Xia D, Wei Y, Sun E, Liu C, Zhu H, Bian H, Wu H, Feng L, Wang J, Liu C
J Virol 94 (2020)
PMID: 32075932
Related structures: EMD-0838

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207846 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Light chain of Fab fragment Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.56 KDa
Source organism: Mus musculus
Heavy chain of Fab fragment Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.73 KDa
Source organism: Mus musculus
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 27.56 KDa
Source organism: Porcine circovirus 2
UniProt:
  • Canonical: F5A4Z4 (Residues: 1-231; Coverage: 98%)
Sequence domains: Circovirus capsid protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.2Å
Relevant EMDB volumes: EMD-0838

Quick links

Citations

11 citation in other articles

Molecular genotypic analysis of porcine circovirus type 2 reveals the predominance of PCV2d in Vietnam (2018-2020) and the association between PCV2h, the recombinant forms, and Vietnamese vaccines.
Doan et al. (2022)
10 more

1 mention without citation

Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
Huang et al. (2020)