› 6kha

Solution NMR

Solution structure of bovine insulin amyloid intermediate-2

Released:
DOI: 10.2210/pdb6kha/pdb
PDB entry 6kha coloured by chain, ensemble of 10 models, front view.
PDB entry 6kha coloured by chain, ensemble of 10 models, side view.
PDB entry 6kha coloured by chain, ensemble of 10 models, top view.
Source organism: Bos taurus
Primary publication:
High-resolution structure of a partially folded insulin aggregation intermediate.
Ratha BN, Kar RK, Brender JR, Pariary R, Sahoo B, Kalita S, Bhunia A
Proteins 88 1648-1659 (2020)
PMID: 32683793

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134251 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01317 (Residues: 85-105; Coverage: 26%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.4 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01317 (Residues: 25-54; Coverage: 37%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 45%
Refinement method: simulated annealing

Quick links

Citations

1 review citation

Amyloid Prefibrillar Oligomers: The Surprising Commonalities in Their Structure and Activity.
Diociaiuti et al. (2021)